7-KETO^TM
Technical Data Sheet

DESCRIPTION
7-KETO^TM is a trademark for our 7-keto-DHEA (7-ketodehydroepiandrosterone)-containing product.

In humans, 7-keto-DHEA is a naturally-occurring metabolite of DHEA (dehydroepiandrosterone).1,2

7-keto-DHEA is clinically proven to be safe,3,4 and it does not convert to active testosterone and/or estrogen.5

STRUCTURE/FUNCTION/USAGE
Like DHEA, 7-Keto-DHEA is associated with a variety of essential human functions. However, unlike DHEA, 7-keto-DHEA is clinically proven to be safe,3,4 and it does not convert to active testosterone and/or estrogen.5 Research has shown that 7-keto-DHEA is more potent than DHEA in strengthening the immune system,6,7 enhancing memory,8 and inducing the activity of various thermogenic enzymes.5, 9-11

FORMULA
Each capsule contains 25 mg of 7-KETOTM.
The product contains no sugar, salt, yeast, wheat, gluten, corn, dairy products, coloring, flavor, or preservatives.

HOW DOES IT WORK?
Research has shown that 7- keto DHEA enhances humoral and cell-mediated immunity.6 Furthermore, 7- keto-DHEA appears to enhance the immune response when the normal immune response is less than optimal.7
In addition, in animal studies, 7- keto-DHEA enhanced memory in mice with impaired memory.8
7- keto-DHEA has also been shown to induce the activity of various thermogenic enzymes.5, 9-11

RECOMMENDATIONS
One capsule two to three times daily, as an addition to the everyday diet.

ADVERSE REACTIONS/ PRECAUTIONS
Use of 7-KETOTM is clinically proven to be safe.3,4

HOW SUPPLIED
60 capsules per bottle.

STABILITY
Store at controlled room temperature, 59o to 86 o F (15 o – 30 o C).

REFERENCES

1. Parker LN. Adrenal Androgens in Clinical Medicine. San Diego: Academic Press, Inc. 1989.

2. Marenich LP. Excretion of testosterone, epitestosterone, androstenedione and 7-ketodehydroepiandrosterone in healthy men of different ages. Probl Endokrinol. 1979;25:28-31.

3. Weeks C, Lardy H. Henwood S. Preclinical toxicology evaluation of 3-acetyl-7-oxo-dehydroepiandrosterone (7-keto-DHEA). The FASEB J. 1998;12:A764. Abstract (4428).

4. Davison MH, Weeks C, Lardy H, et al. Safety and endocrine effects of 3-acetyl-7-oxo-DHEA (7-keto-DHEA). The FASEB J. 1998;12:A764. Abstract (4429).

5. Lardy H, Partridge B, Kneer N et al. Ergosteroids: induction of thermogenic enzymes in liver of rats treated with steroids derived from dehydroepiandrosterone. Proc Natl Acad Sci USA. 1995;92:6617-6619. Abstract.

6. Nelson R, Herron M, Weeks C, et al. Dehydroepiandrosterone and 7-keto-DHEA augment interleukin 2 (IL 2) production by human lymphocytes in vitro. Presented at the 5th Conference on Retroviruses and Opportunistic Infections; February 1-5, 1998; Chicago, Illinois. Abstract (596), p 49.

7. Lardy H, Treatment of Alzheimer’s disease and modulation of immune system with ?5-androsternes. 1998. United States Patent: 5707983.

8. Shi J, Lardy H. 3?-hydroxyandrost-5-ene-7,17-dione (7-keto-DHEA) improves memory in mice. The FASEB J. 1998;12:A764. Abstract (4427).

9. Su CY. Lardy H. Induction of hepatic mitochondrial glycerophosphate dehydrogenase in rats by dehydroepiandrosterone. J Biochem. 1991;110:207-213.

10. Bobyleva V, Bellei M, Kneer N et al. The effects of ergosteroid 7-oxo-dehydroepiandrosterone on mitochondrial membrane potential: possible relationship to thermogenesis. Arch Biochem Biophys. 1997:341:122-128.

11. Lardy H, Reich IL. ?5-androsternes useful for promoting weight maintenance or weight loss and treatment process. 1996. United State Patent: 5506223.

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